Assays

High Volume HLA-A, B, DR Typing
HLA Class I – Intermediate Resolution(2)
HLA Class I – High Resolution(1)
HLA Class II – Low Resolution(3)
HLA Class II – High Resolution
HLA Single Locus Supplemental High Resolution (Class I or II)
HLA DQA1, DPA1 or DPB1
HLA B27
HLA ABC Antibody Screen
HLA Crossmatch
HLA Matched Platelet Donor Search
Percent CD34+ Cells
Hematopoietic Progenitor Cell (Colony Forming Unit) Assay

(1) High Resolution provides the first 4 or more numbers of an allele’s name that has been approved by the World Health Organization Nomenclature Committee for Factors of the HLA System. If the first 4 numbers of two alleles are identical, the proteins encoded by those alleles are identical. Letters that occur in longer allele names define the level of expression of that protein. “L” indicates a low expression allele, and “N” indicates a null, or non-expressed allele.

(2) Intermediate Resolution provides at least the first 2 numbers of an allele’s name that has been approved by the WHO Nomenclature Committee for Factors of the HLA System. Alleles for serological split antigens, such as B60 and B61 (both are B*40 alleles) will always be defined as to which serological group they belong. If available, a code supplied by the National Marrow Donor Program will be used to delineate the exact group of high resolution alleles that are included as possible alleles. This frequently gives information about high resolution mismatches even before high resolution testing is performed. If a high resolution result is obtained, the full name of the allele will be reported.

(3) Low Resolution only provides the first 2 numbers of an allele’s name that has been approved by the WHO Nomenclature Committee for Factors of the HLA System. Most of the time, this is sufficient to define the serologically distinct antigens of the HLA System.